National Sleep Foundation

Chapter 4: Primary Hypersomnias


The treatment of Kleine-Levin Syndrome is not well-established. Stimulants (specifically, amphetamines) have been shown to effectively decrease sleepiness during active episodes, but have no effect on behavioral or cognitive disturbances among these patients. Lithium has been demonstrated to prevent relapse in certain patients.67


  1. Arnulf I, Zeitzer JM, File J, Farber N, Mignot E. Kleine-Levin syndrome: a systematic review of 186 cases in the literature. Brain. 2005;128:2763-2776.