National Sleep Foundation

Chapter 4: Primary Hypersomnias


As noted, Kleine-Levin Syndrome is characterized by recurrent episodes of hypersomnia associated with disturbances in mood (e.g., irritability, aggression, compulsivity) and cognition (e.g., de-realization, confusion, hallucinations, depression), compulsive eating, and hyper-sexuality.64 These outcomes severely disrupt the lives of patients with KLS, who not only miss out on large portions of their lives, but also suffer negative consequences to their social, educational, and professional lives as a result of the disease.


  1. Gadoth N, Kesler A, Vainstein G, Peled R, Lavie P. Clinical and polysomnographic characteristics of 34 patients with l-Levin syndrome. J Sleep Res. 2001;10:337-341.